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Researchers with California-based Salk Institution for Biological Studies developed a new diet pill compound capable of tricking the metabolism into thinking a meal had been consumed. Based on the design of the drug, fat is burned, which in turn creates room for new calories. However, there are a number of experts who caution consumers about using so-called miracle drugs for weight loss alone.
One of the unique aspects of the drug known as Fexaramine is that it works within the intestine only so at no point does it get into the bloodstream. As such, the diet pill is deemed to be a much safer product when compared to diet pills produced prior such as Fen-Phen. These earlier drugs cause the heart to beat faster, not to mention unpleasant side effects.
At this time, this new diet pill, Fexaramine, has been tested only in laboratory mice. As reported by Ronald Evans, lead author of the study and director of the Gene Expression Laboratory linked to Salk Institution in the recent Nature Medicine journal, if the same benefits are proven in studies involving primates, then within a few years clinical trials can begin on humans.
With Fexaramine, a genetic switch within the body connected to metabolic and eating control is switched. As explained by Evans, the diet pill is taken orally at which time it tricks the body into thinking a meal had been consumed. Interestingly, the mice tested did not have less appetite and in fact, they ate the same amount of food when on the pill versus off yet they lost weight.
In the paper written by Evans, there could come a day when Fexaramine becomes a nonsurgical choice to vertical sleeve gastrostomy surgery, which has been widely used in the fight against obesity. Currently, statistics show that roughly 33% of people in the US are in the “obese” category.
Almost two decades ago, Evans was involved with laboratory studies whereby the molecular switch that turns off responses in the body to eating were conducted. As part of these studies, absorption, nutrient transfer, and digestion were also researched.
While waiting for Fexaramine FDA approval, tests in mice shows this switch can be flipped, which produces much the same reactions as what Evans discovered previously but without producing side effects. In addition to the work being done at Salk, there are a number of other experts working on approaches very similar but so far, Fexaramine surpasses all others.
In a statement Evans said with this new diet pill, it is as if the body goes through the entire process of consuming a meal but without eating anything. As a result, people are expected to lose weight. In addition, this drug reduces cell inflammation, contributes to brown fat that burns calories, and cuts down insulin resistance.